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PD03

Household smoking and markers of atopic sensitisation in children: a systematic review and meta-analysis

Thursday, 17 October, 2013 - 11:34
Board 3

Poster Presenter: Wojciech Feleszkowfeleszko@kliniczny.pl
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Household smoking and markers of atopic sensitization in children: a systematic review and meta-analysis

Introduction
Environmental tobacco smoke exposure (ETS) → impaired lung function, and aggravation of allergic asthma in children:
1. irritant effect → heightened bronchial hyperreactivity
2. alterations in circadian variations in pulmonary function
3. sensitivity to allergens

STUDY AIM:
To systematically review data from cross-sectional and cohort studies on the effect of ETS on markers of allergic sensitization (serum IgE, skin-prick tests) in children
 
Methods
MESH heading : [tobacco smoke] and/or :
#1 {passive, second-hand, second hand, involuntary, parent*, maternal, mother*, paternal, father* or household} and {smok*, tobacco* or cigarette*}
#2 {atopic disease or atopy or IgE or globulin E or eosinophil* or skin prick test, skin-prick, SPT}
#3 {e.g., child* or adolescent*}
 
Extracted
N= 1,606 Abstracts
 
Studies included   (N= 25)  :  
 • tIgE    N=8        
 • sIgE    N= 6          
 • SPT    N=14
 

Results
 
ETS exposure & IgE :   ↑  by 89,8 kU/l   [95%CI: 30,9 - 149]
ETS exposure & specific IgE: OR=1.12 [95%CI: 1.00-1.25]
 
ETS exposure & skin-prick tests OR=1.15 [95%CI: 1.04-1.28]
 
Conclusions
♦ This study supports an association between tobacco smoke exposure in early childhood and ­­  risk of allergic sensitization by ca. 12-15%
♦ This study  underscores ETS as one of the most important, avoidable risk factor for development of allergic disease in children