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Calcific Aortic Valve Disease after Thoracic Radiation Therapy: an Immunohistochemical Study

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Calcific Aortic Valve Disease after Thoracic Radiation Therapy: an Immunohistochemical Study

Radiation-associated aortic valve stenosis is frequently seen as a late sequela after thoracic radiotherapy. Although the clinical relationship between thoracic radiotherapy and valvular dysfunction has been established, the mechanism behind the accelerated aortic valve stenosis remains unclear.

The aim of this study was to determine whether increased inflammatory cell infiltration is present in aortic valves after radiotherapy and whether radiotherapy induces leaflet fibrosis and calcification.

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