The role of Follistatin-like 1 (Fstl1) in postnatal valve growth and disease
Stuti Prakash1, Lorena Flores Ruiz3, Quinn D Gunst1, Jan M Ruijter1, Jose Luis De La Pompa2, Luis J Jimenez Borreguero3, Maurice van den Hoff1.
1Department of Anatomy, Embryology and Physiology, Academic Medical Center, Amsterdam, The Netherlands, 2Program of Cardiovascular Developmental Biology, Department of Cardiovascular Development and Repair,
3Department of Epidemiology, Atherothrombosis and Image, Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain
Follistatin-like 1 (Fstl1) is a glycoprotein of the SPARC (Secreted Protein Acidic Rich in Cysteine) family and is involved in various intercellular signaling pathways. Different studies show a crucial role for Fstl1 during development including heart, lung and skeletal development. Disruption of Fstl1 results into variety of developmental defects , mainly in cardiac, lung and skeletal formation.
Fstl1 is predominantly expressed in the non-myocardial component of the heart and also in the myocardial component to a lesser extent. Fstl1 expression levels are up-regulated in rodent models of myocardial infarction or pressure overload hypertrophy. In human acute coronary syndrome there is an increase in Fstl1 levels and these levels correlates with the infarct size and mortality.