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434 posters,
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1064 institutions
1022
IMMUNOLOGICAL HYPORESPONSIVENESS TO PNEUMOCOCCAL CONJUGATE VACCINES (PCV) ASSOCIATED WITH REPEATED USE OF PPV23 IN ASPLENIC β-THALASSEMICS: A 7-YEAR FOLLOW-UP
Aghia Sophia Children's Hospital, University of Athens Department of Infectious Diseases,
University of Athens Endocrine Division, Department of Pathophysiology,
Aghia Sophia Children's Hospital, University of Athens Thalassemia Unit,
PPV23-associated immunological hyporesponsiveness has been clearly documented previously. A mechanism, involving depletion of the serotype-specific memory B-cell pool by polysaccharide antigens, has been suggested to be responsible for this phenomenon. The impact of PPV23 vaccinations on immunological memory established by conjugate vaccines (PCVs) is unclear. Splenectomised individuals are at increased risk and according to current guidelines should receive repeated PPV23 immunizations.
