Title: CORISPE, THE SPANISH COHORT OF HIV-INFECTED CHILDREN: CURRENT SITUATION

Background and aims:CoRISpe, a Spanish cohort including HIV-infected pediatric patients,

yielding interesting information in our country.

Methods: A cross-sectional study was performed

Data were collected until September 2011.Most recent CD4 (count or percentage depending on

patient´s age) and plasma viral load were evaluated.

Results: The CoRISpe has recruited 838

patients.302 are over 18 years old. 536 HIV-1-infected children followed in 53 different hospitals

were studied.The median age was 12,6 years (range:0,04-17,98). Vertical transmission was in

(97%). 53,7% were female.Most of the children were born from Spanish parents (67,9%) but in

the last years an increasing number of patients were immigrants or were born of

immigrants,mainly in Subsaharan Africa (19,6%) and South America (7,5%). 4,6% of patients

has Hepatitis C Virus (HCV). 23% of the children had developed AIDS. 95% were receiving

HAART,and 5% were without treatment.The most common regimen included two nucleoside

reverse transcriptase inhibitors (NRTI) plus a protease inhibitor (PI) (46,6%).The most used

antiretroviral were Lopinavir/r (51,1%), 3TC (40%), ABV (39,1%) and FTC (30,2%). Median CD

was 834/mm 3 (IQR: 601-1143) and median CD4% was 33,3% (IQR:28,2-38), most of the

children had a CD4% over 25% (88,8%) and CD4 over 500/mm 3 (86,7%). 74,1% of the patients

receiving HAART had an undetectable plasma viral load.

Conclusions:

 The institution of a National Cohort has led to an improve in the knowledge of pediatric HIV infection in Spain.In the

last years an increasing number were immigrants.A high proportion of vertical-infected children

are becoming adolescents and adults.Most of the children were receiving HAART and they had

a good immunological response.

Author Keywords: HIV pediatric cohort, HIV children

Paediatric HIV