Title: CORISPE, THE SPANISH COHORT OF HIV-INFECTED CHILDREN: CURRENT SITUATION
Background and aims:CoRISpe, a Spanish cohort including HIV-infected pediatric patients,
yielding interesting information in our country.
Methods: A cross-sectional study was performed
Data were collected until September 2011.Most recent CD4 (count or percentage depending on
patient´s age) and plasma viral load were evaluated.
Results: The CoRISpe has recruited 838
patients.302 are over 18 years old. 536 HIV-1-infected children followed in 53 different hospitals
were studied.The median age was 12,6 years (range:0,04-17,98). Vertical transmission was in
(97%). 53,7% were female.Most of the children were born from Spanish parents (67,9%) but in
the last years an increasing number of patients were immigrants or were born of
immigrants,mainly in Subsaharan Africa (19,6%) and South America (7,5%). 4,6% of patients
has Hepatitis C Virus (HCV). 23% of the children had developed AIDS. 95% were receiving
HAART,and 5% were without treatment.The most common regimen included two nucleoside
reverse transcriptase inhibitors (NRTI) plus a protease inhibitor (PI) (46,6%).The most used
antiretroviral were Lopinavir/r (51,1%), 3TC (40%), ABV (39,1%) and FTC (30,2%). Median CD
was 834/mm 3 (IQR: 601-1143) and median CD4% was 33,3% (IQR:28,2-38), most of the
children had a CD4% over 25% (88,8%) and CD4 over 500/mm 3 (86,7%). 74,1% of the patients
receiving HAART had an undetectable plasma viral load.
The institution of a National Cohort has led to an improve in the knowledge of pediatric HIV infection in Spain.In the
last years an increasing number were immigrants.A high proportion of vertical-infected children
are becoming adolescents and adults.Most of the children were receiving HAART and they had
a good immunological response.
Author Keywords: HIV pediatric cohort, HIV children