AbstractAim: CRPs are a major cause of nosocomial infections with an increased impact on morbidity, mortality, and health-care costs. Knowledge about CRP infections in children is very limited. We present the course of children with CRP infections notified to the National Surveillance System of Greece. Methods: Data were collected prospectively from Greek hospitals. Results: From Jan through Oct 2011, 47 children (median age: 2 years) were notified. Underlying conditions existed in 72% of them. Infections were: pneumonia (16 cases; 34%, including 13 (81.3%) ventilator-associated), bacteremia (13; 27.7%), urinary tract infection (12; 25.5%), and surgical site infection (6; 12.8%). Isolates were Acinetobacter baumanii
(20; 40.8%), Pseudomonas aeruginosa
(19; 38.8%), and Klebsiella pneumoniae
(10; 20.4%). The first positive culture occurred a median of 22 days (0-256) after admission. 31 (65.9%) children were hospitalized in an Intensive Care Unit. Regarding risk factors for colonization, 15 (31.9%) had a history of hospitalization the prior 6 months; 30 (63.8%) and 25 (53.2%) had received broad-spectrum antibiotics or carbapenems the prior 6 months, respectively; 34 (72.3%) were on mechanical ventilation; 29 (61.7%) had a central vascular catheter and 26 (55.3%) had a urine catheter. Eleven (23.4%) children died a median of 7 days (0-47) after the first positive culture. Conclusions: Infections due to CRPs are associated with an increased morbidity and mortality among children.