ePostersLive by SCIGEN TECHNOLOGIES
388 posters, 
12 sessions, 
2210 authors, 
613 institutions

PP009

CLINICAL PREDICTORS OF CARDIAC MIBG SYMPATHETIC FUNCTION IN TYPE 1 DIABETIC PATIENTS

Thursday, 6 October, 2011 - 16:12
Board 1

Clinical predictors of cardiac MIBG sympathetic function in type 1 diabetic patients

Aim. This study aimed to identify potential clinical predictors of cardiac sympathetic dysfunction as assessed with 123I metaiodobenzylguanidine (MIBG) imaging in patients with type 1 diabetes mellitus (T1DM). Patients - Methods. Forty-nine patients (20 female), aged 36±10 years, with a duration of T1DM 19±6 years were enrolled prospectively. We used the following tests for autonomic dysfunction assessment: mean circular resultant (MCR), Valsalva maneuver (Vals), postural index (PI) and orthostatic hypotension (OH). Patients underwent cardiac MIBG imaging and the ratio of the heart to upper mediastinum count density (H/M) at 4 hours post-injection was calculated (abnormal if H/M<1.80). Results. Vals and PI could not determine MIBG abnormality but OH could (p values of 0.684 0.173, 0.315 versus 0.045, respectively, chi-square statistic or Fisher’s exact test). Moreover, 1, 3 or 4 abnormal clinical tests or gender differences could not predict abnormal H/M, but 2 abnormal tests could (p values of 0.811, 0.173, 1.000, 0.738 versus 0.011, respectively). Patients with an abnormal H/M were older (38±9 versus 30±9 yrs, p=0.019) but had not significantly longer duration of T1DM (20±6 versus 15±6 yrs, p=0.059, Mann-Whitney) in comparison to those with a normal H/M. In binary logistic regression analysis (in which variables with a p<0.020 were entered) age was found the only significant independent predictor of an abnormal H/M. Conclusion. In patients with T1DM cardiac sympathetic system impairment in MIBG examinations may be determined suboptimally with autonomic function tests. Moreover, although age may be considered in the interpretation of clinical tests, age remains a significant independent predictor of abnormal MIBG studies.  

 

 

Your rating: None Average: 4 (2 votes)