ePostersLive by SCIGEN TECHNOLOGIES
388 posters, 
12 sessions, 
2210 authors, 
613 institutions

PP345

LONG-TERM PROGNOSTIC VALUE OF PRO-BNP IN PULMONARY EMBOLISM

Thursday, 6 October, 2011 - 17:00
Board 17

Prospective studies have demonstrated that clinical factors, echocardiographic right ventricular dysfunction and cardiac biomarkers are independent predictors of short-term mortality in patients with PE. However, longer-term predicting factors are not well known.

Part of Session

Cardiovascular Diseases

Your rating: None Average: 5 (2 votes)

Full Text

Introduction

false
false
false
false
Prospective studies have demonstrated that clinical factors, echocardiographic right ventricular dysfunction and cardiac biomarkers are independent predictors of short-term mortality in patients with PE. However, longer-term predicting factors are not well known.

none

Materials & Methods

false
false
false
false
We evaluated the long-term meaning of Pro-BNP measured early during the admission because of acute pulmonary embolism in successive patients, and its influence in long-term survival.

none

false
false
false
false
Plasma Pro-BNP was measured (Elecsys Roche Diagnostics, Mannheim, Germany) in the first 48 hours after the diagnosis of pulmonary embolism was obtained.

none

false
false
false
false
Follow up of patients was carried out through the computerized medical records of Health Service of Navarra and by means of telephone calls.

none

false
false
false
false

none

false
false
false
false

none

images/image1316429308678.png
150
128
user
center

row
19.76

false
false
false
false

none

false
false
false
false

none

false
false
false
false

none

images/image1316428766445.png
120
94
user
center

row
19.76

false
false
false
false

none

false
false
false
false

none

false
false
false
false

none

images/image1316428436765.png
143
80
user
center

row
19.76

false
false
false
false

none

false
false
false
false

none

false
false
false
false

none

false
false
false
false

none

images/image1316429472713.png
141
137
user
center

row
19.76

false
false
false
false

none

false
false
false
false

none

false
false
false
false

none

Results

false
false
false
false
One hundred and ninety-three patients were evaluated, median age 76 years (I
none

false
false
false
false
QR
none

false
false
false
false
16), female 52%
none

false
false
false
false
.
none

false
false
false
false
PE was diagnosed by
none

false
false
false
false
CT
none

false
false
false
false
angiography in 188 (97%) patients and by means of pulmonary scintigraphy in 5 (3%) patients.
none

false
false
false
false

none

false
false
false
false

none

false
false
false
false
During a mean time of follow up of 28 months, 45 (23%) patients died, 14 (7%) of them during the admission index.
none

false
false
false
false
Causes of delayed death were: Pulmonary embolism 21, hemorrhage 4, cancer 3, death by other cardiovascular causes 7, infections 6, other causes 2, unknown 1 patient.
none

false
false
false
false

none

false
false
false
false

none

false
false
false
false
Median Pro-BNP in dead patients was 3,070 (IQR 7243) ng/L, while in survivors was 701 (IQR 2488) ng/L (p<.001).
none

false
false
false
false

none

false
false
false
false

none

false
false
false
false

none

false
false
false
false
In multiple logistic regression, age, pro-BNP and systolic blood pressure, were independent variables associated with death.
none

false
false
false
false

none

false
false
false
false

none

false
false
false
false
At 10 months of follow up, log rank analysis showed different probability of survival (p=.012) with a difference in mortality rate of 22% in patients with pro-BNP higher than 500 ng/L in index episode.
none

false
false
false
false

none

Conclusions

false
false
false
false
In the setting of acute pulmonary embolism, among other factors, pro-BNP measured at index admission could represent a medium-term prognostic factor, signalling probability of overall death. However, beyond 10 months pro-BNP failed as prognostic factor.
none